Publications

La détection des parathyroïdes par autofluorescence lors de thyroïdectomie totale

Randomized controlled trial comparing white light with near-infrared autofluorescence for parathyroid gland identification during total thyroidectomy 
Fernando Dip MD, FACSa,c; Jorge Falco MD, FACSa; Silvina Verna MDa; Marcos Prunello MDb; Matias Loccisano MDa; Pablo Quadri MDa; Kevin White MD, PhDd; Raul Rosenthal MD, FACSc  

a Instituto Argentino de Diagnóstico y Tratamiento, Buenos Aires, Argentina 
b Department of Surgery, Universidad Nacional de Rosario, Argentina
c Section of Minimally Invasive Surgery, Department of General Surgery, Cleveland Clinic Florida, Weston, FL
d ScienceRight Research Consultations, London, Ontario, Canada
BACKGROUND:
Parathyroid glands are difficult to identify during total thyroidectomies, and accidental resection can lead to problematic postoperative hypocalcemia. Our main goals were to evaluate the effectiveness of using near-infrared light (NIRL) autofluorescence intraoperatively for parathyroid gland identification and to measure its impact on postoperative hypocalcemia incidence.

STUDY DESIGN:
Total thyroidectomies were performed on 170 patients with different thyroid pathologies, block-randomized (1:1) into 2 equal groups. Among controls, traditional overhead white light (WL) was used throughout. In the experimental group, NIRL was used to enhance parathyroid gland recognition before thyroid dissection. The number of parathyroid glands identified was compared after thyroid dissection in controls using WL vs pre-dissection in the experimental using NIRL and with WL vs NIRL before thyroid dissection in the experimental group. Postoperative serum calcium levels and hypocalcemia rates were compared.

RESULTS:
The mean number of parathyroid glands identified pre-dissection with NIRL was the same identified post-dissection with WL (3.5 vs 3.6). In the experimental group, converting from WL to NIRL increased the number of glands detected from 2.6 to 3.5 (p < 0.001), and revealed at least 1 previously missed gland in 67.1% of patients. Calcium levels ≤7.5 mg/dL were one-tenth as common in the NIRL group (p = 0.005). The adjusted odds of hypocalcemia developing increased by 15% for every 5-g increase in thyroid gland weight (odds ratio 1.15; 95% CI 1.06 to 1.25). All hypocalcemia resolved within 6 months.

CONCLUSION:
Using NIRL during thyroidectomy increases intraoperative identification of parathyroid glands, enhances their detection before thyroid dissection, and decreases the incidence of postoperative hypocalcemia.
EN SAVOIR PLUS :